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7 Supplements That Help Dogs With Separation Anxiety Feel Safe

Doggone Well Staff by Doggone Well Staff
April 17, 2025
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MidJourney



Separation anxiety can leave dogs feeling nervous and overwhelmed when their humans leave. Signs like barking, chewing, pacing, or accidents inside are stressful for both the pet and the owner. Fortunately, there are natural supplements that support relaxation and help dogs feel more secure during these moments. Here are seven options that may ease anxiety and promote a calmer state of mind.

Hemp Mushroom Chews

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The iHeartDogs Hemp Mushroom Chews – Mobility, Calming & Immune Support (on Amazon) are packed with soothing ingredients like organic hemp, reishi mushrooms, and valerian root. Hemp is known for its calming properties, helping to ease anxious behaviors without making your dog drowsy. The addition of mushrooms like reishi and maitake may also support immune balance and mental clarity. Many dog owners find these chews especially helpful before leaving the house or during stressful events like storms or travel. They’re also free of artificial additives, making them a gentle and thoughtful option for long-term use.

L-Theanine Supplements

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L-Theanine is an amino acid commonly found in green tea. It works by supporting the production of calming neurotransmitters such as GABA and serotonin. In dogs, this can translate to reduced signs of separation anxiety, including whining or destructive behavior. Supplements with L-Theanine often come in chewable form or capsules that can be opened and sprinkled over food. It typically takes effect within 30 to 60 minutes, making it a good option for predictable events like daily departures or known triggers.



Melatonin for Dogs

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Melatonin is a hormone naturally produced by the body that regulates sleep. When used in small, dog-safe doses, it may help calm pets who feel restless or stressed when left alone. Melatonin is particularly useful for dogs who have trouble settling down at night or during crate training. Some products combine melatonin with other soothing herbs like chamomile or passionflower to enhance the calming effect. Always use products made specifically for pets to ensure proper dosing and avoid additives.

CBD Oil

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CBD oil and hemp-based treats have become popular for managing stress in both humans and pets. In dogs, they may promote a sense of calm without the high associated with THC. Some pet owners report that CBD has helped reduce pacing, barking, and other signs of stress when their dog is left home alone. Look for formulas that are third-party tested and designed for pets, like tinctures that can be mixed into food or treats that dogs enjoy. Effects usually begin within 30 to 45 minutes.

Chamomile-Based Chews

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Chamomile has been used for centuries to promote relaxation and reduce anxiety. In dogs, chamomile-based chews may offer a mild calming effect that helps reduce tension when the house is empty. These supplements are often combined with other natural ingredients like ginger or passionflower to ease nervousness and promote comfort. They’re especially helpful for dogs that get anxious during certain times of day or in new environments.



Probiotics for the Gut-Brain Connection

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There’s a strong link between gut health and emotional regulation, sometimes called the gut-brain axis. Probiotics may help regulate mood by supporting digestive health, which in turn helps balance neurotransmitter production. Dogs with sensitive stomachs or irregular bowel movements might benefit from a daily probiotic that also eases their mental state. Though not traditionally thought of as a calming aid, probiotics can be part of a more holistic approach to anxiety management.

Magnesium-Rich Supplements

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Magnesium plays a role in muscle relaxation and nervous system regulation. In dogs, a lack of magnesium may contribute to heightened stress or restlessness. Some calming chews and powders include magnesium alongside other supportive ingredients like taurine and vitamin B6. Together, they may reduce overstimulation and support relaxation. Be sure to check with your vet before adding magnesium, especially if your dog is on other medications or has existing health conditions.

Gentle Ways to Help Dogs Feel More Secure

7 Supplements That Help Dogs With Separation Anxiety Feel SafeMidJourney

When supplements are used consistently and paired with behavioral training, many dogs experience significant improvements in how they handle being alone. Products like the iHeartDogs Hemp Mushroom Chews – Mobility, Calming & Immune Support (on Amazon) offer a thoughtful blend of calming ingredients that address anxiety from multiple angles, making them a smart choice for pet parents looking to support their dog’s emotional well-being. Disclosure: As an Amazon Associate, iHeartDogs earns from qualifying purchases.





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